Nick Andrews 37 min

Unveilng the Applied Biosystems SeqStudio Flex Genetic Analyzer for Human Identification


Watch how the Sacramento County Crime Lab DNA analysts Flex their Power in the unveiling of the new SeqStudio Flex Genetic Analyzer.



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[Music]

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I'm Nick Andrews, product manager at Thermafisher Scientific,

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part of the human identification team, or HID as it's known.

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Today we're here in sunny Pleasanton, California, the home of the HID Research

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and Development team.

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We have something super exciting to share with you today. We are ready to

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unveil the latest and

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greatest genetic analyzer, the Seek Studio Flex. Now you may know that the Seek

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Studio Flex has

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been available for the research community, but we're ready for forensic prime

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time. So today we have

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three forensic experts from the Sacramento County Crime Lab who are here to put

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it through its

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paces. They'll get to see all the greatest features like the four-plate deck

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with continuous plate

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loading, sample reprioritization, the integrated data collection software, and

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the remote monitoring

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and remote troubleshooting features. I know this instrument is going to blow

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them away and it's

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going to blow you away too. So let's go meet the team. I cannot wait to see

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what they think.

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My name is Ryan Nickel and I work for the Sacramento County Crime Lab. I'm a

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criminalist there and

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I'm also a crime scene lead at the laboratory. I'm Natalie Jones. I also work

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at the Sacramento

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County Crime Lab as a criminalist and I'm also the local codist administrator.

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I'm Danielle Frost.

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I'm also a criminalist at the Sacramento County Crime Lab and I'm in training.

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Thank you so much

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for introducing yourselves and thank you very much for coming in. This is great

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. You all seem to

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have a lot of different experiences so this is going to be a really exciting

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time. Just to confirm,

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you're all forensic scientists and none of you are paid actors. No, I'm not

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trying to say it.

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Right. So what do you actually know about the Sikh Studio Flex? It's been out

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for the research

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community for a while so have you heard anything about it? Nothing. Only the

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name which I saw in

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the email that we got. CE Instrument. Yep, that's right. It's our brand new

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latest and greatest

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genetic analyzer that we have. It got released for our research community a

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while ago and now we're

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ready to avail it for the HID market. So we want you guys to be the first look

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at this instrument.

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So we're the first forensic scientists to this. You're going to be the first

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forensic scientist

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in the world to touch this instrument. Wow, it's exciting. Well, then this is

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exciting.

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This is going to be exciting. It's cool. It's going to be great. So if you had

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a new CE Instrument

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for your lab, what would you want it to do? Would there be anything you'd be

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looking for?

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I would probably something along the lines of if one plate is running, if you

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could actually load

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a plate on while the other plate is running would be great. That would be a big

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help in our laboratory

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for sure. Glad you say that. I think it would be nice to be able to load more

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than two plates.

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Four, maybe six. That way we can get everyone at the lab working on at the same

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time and just

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turn the instrument on and let it go. I would love for the software to be

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really user-friendly and

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to be able to easily load on your plate and press buttons. Say go.

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And you mentioned that you were currently in training. So how has it been

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learning how to use

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CE in the application of forensic DNA? It's been challenging just learning

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memorizing the steps.

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There's so many steps that come with the CE in managing the software. So it's a

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question of

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where do I look for this button? It's kind of hidden away in this corner. So

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that's been difficult.

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Right. Yes. I know for my time in the lab. You all have 3500s in your lab,

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correct?

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Yes. So what do you like using about the 3500 or how has it helped you?

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I like the anode and cathode buffer that it's just you don't have to load it or

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make any

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mixture. It comes in a pre-made box. You can throw that right on. I also like

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the,

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it scans the polymer for us and tells us how many injections. So that's nice. I

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like that we have

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our lab uses 24 capillaries so we can get through a lot of samples pretty quick

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Yeah, we use USBs. So we have to go into the run room, load it onto the USB,

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take it back to our

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desk, load it into the software. So I hadn't thought about that but that would

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be nice if we could

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like remote into that computer from our desk, pull our data, put it right into

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the software.

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I would love that. Yeah. I'm sure actually other analysts that are, you know,

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we're allowed to work from home a couple days a week would actually like to

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remote in, get their

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data and actually analyze data from home. If you need some re-injections, you

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don't have to worry

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about re-plating when you come in the next day. I'd be cool. Can this

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instrument tell us at our

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desk that something's wrong? We can pop in there and fix it. Well, I don't want

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to give too much

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away but it might have some of these features that you've been looking for. I

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like it. I'm pretty

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happy that you brought these up but I think maybe we should probably get in

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there and actually see

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this instrument. All right. Let's see it. Cool. Let's do it.

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Okay. Oh Ryan, Natalie, Danielle, Yiga Beaver. I would very much like to

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introduce to you

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the new six new blocks. Wow. Very sweet. Yes. That is cool. No, can I have it?

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Yeah. How can we

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touch it? Go ahead. I had my phone. Now you can get in there. Like the looks

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very similar

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back there. Yeah. Can we take a closer look? Please. I'm assuming touch screen.

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I want to

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know how many plates. Can I touch the screen? Can we open it? Yeah. Boom. Four

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plates guys.

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Four. You can see the drawers unlocked. Go ahead. To oh, they're there. They're

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there.

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Yep. That's fun. So you can load while it's running. Yes.

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Continuous plate loading. Sample re-prioritization. So you can load a plate. It

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could be injecting.

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You could then load another plate. You could say my injections more important.

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You could put that

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to the top of the list and it will take that plate. You could have four plates

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in there.

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When one plate is finished, you could open that drawer to take it off and there

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's a new spot open

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again. You could maybe wait until the end of the day, load four plates at once

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and it can just run

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all night and then you can come back into data in the morning. I know one of

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your concerns might

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have been about, well, what happens if there's an injection failure or

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something like that?

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But this also has a remote monitoring. So you can get alerts at your computer.

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You can get up on

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your phone. You can even do re-injections from your phone with this instrument.

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So if you are working

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remotely, you can do that. Yes. And for those of you who maybe use a 31-30 back

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in the day,

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while you have the barn doors, this instrument has the same type from there.

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Very cool. Easy to get

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in there. Obviously your oven door. You may not be able to newly designed array

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as well, so it's

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actually easier to install than even the 3500. I love that. It looks easier too

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. You can kind of

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see just where the little buttons are there. Pop in out. Exactly. So can I open

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the drawer right

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now to the instrument? Yeah, as long as that screen says the drawer is unlocked

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, you can open that drawer

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at any point. Go ahead. My question was, is there like an arm that kind of

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grabs those plates and

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takes it up to be analyzed? That's exactly right. So the arm will pick up the

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plate and move it up

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to where the capillaries are, so you can actually do the injection itself.

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So that drawer is unlocked at any point during the run, so you can load plates.

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The only time it

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would be locked is when an injection is in place. Just for safety reasons, you

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've got high voltage

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running through there. But otherwise you can load plates on there. That screen

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will also tell you

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when you have plates that are present on there, so you can see what is linked

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and you know if there's

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available space on it. And do this plates set in or do they clip in? They just

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sit on top of there.

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So as long as you put them in that plate cradle, then they just sit in there

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and they wait for the

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arm to come and pick them up. Very cool. What about the runtime? It's actually

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about the same as the

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3500, so it's kind of around the same time that you had before. A couple of

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other features while we

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have the drawer open, there's also an integrated barcode scanner in there. So

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if you use barcoated

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plates, it can read that so that you actually know what you're linking and you

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can verify it.

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As before, you just have to make sure that you put the plate in the right place

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This time you don't. I see two USB ports right there. Is that to bring in our

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data and it automatically

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kind of populates into the screen there? So we knew that there's obviously a

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lot of different

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options that you can have when you want to transfer data. This instrument does

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have cloud

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connectivity and local area network as well. So you can network the instrument

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on your local

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area network in the lab. You can set up your plates from your office and you

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can have those plates

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loaded directly onto the instrument through a piece of software called plate

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manager,

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which we'll show you in a bit. And then you could also do a USB, so you could

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put it into like your

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standard CSV or text file, load it onto the instrument, or you could do it

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through the cloud.

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So you could use plate manager on the cloud, set up your plate and it will

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remotely send that

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plate to the instrument itself. That's cool. A bunch of different options.

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One thing I did want to do is introduce you to two of our R&D scientists who've

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been working

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really hard on the validation of this instrument. They are going to help us set

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up a run and get

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the instrument going and teach you how to use the instrument thoroughly. So

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what do you say we go

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meet them? Yeah. All right. Hi everybody, my name is Dan Sunil. I'm a staff

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scientist and

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a summer fisher. I've been working on this project for over one year. So today

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I'm going to show you

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how to use the plate manager. That's a software used for creating your files

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for running the

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samples on six U2FLEX. So we have two different versions. One version is on the

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cloud. Another

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version is on the desktop. So this is the version on cloud. So you can create

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your file from the

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scratch by clicking on this guy here, or you can open a file which has been

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saved on cloud,

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or from your computer. Or if you want to use a recently used file, you can

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click on this one.

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You can check, see whether it's correct or not. If everything is correct, so

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you can send this to

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the machine directly. You can choose multiple instruments at the same time and

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click on OK.

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So then this file would be sent to your instruments. Or you can just choose one

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of them. So like

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today, I'm going to just send this one to this instrument. So after you see it,

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you just click

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OK. So now the file is on your instrument. You are ready to run your sample on

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the instrument.

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And also I'm going to show you how to create a file using the plate manager. I

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will be using

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the desktop version today. So I'm going to show you how to create a plate file

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from the scratch.

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So to do that, just click on this one here. Then you get all of these things by

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default.

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You can change your name here. You can change the name of the file. Or you can

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just use the default

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file name. If you say OK, all the parameters here are correct. So you click on

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Next.

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Then you can click on the carbon. You want to put your samples in. And then you

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can come here.

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From here, you choose the injection protocol. So today, I'm going to show you

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how to

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choose this one. That's for the J6 die. So after you click on that, see all the

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other parameters,

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you know, show up here. After that, you click on here. So then you can put the

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name of the files

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in there. So what I do, I just, you know, I have prepared everything. So I just

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copy the thing here

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and then paste it to the software. Sample name, I click on this one and control

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V.

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So then the file names are pasted here. And also you can put the panel names

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here.

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So these are the panel names. All of them here are used globe file, IQC panel.

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So click on the

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software here. So then you get to this panel. Okay, so you click on the first

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one.

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You click on control V here. So in the file, these are the panel names. And

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then I put the

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k-link here. I highlighted everything here and then control C.

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And put it into the first custom fields. Then control V. Okay, after that, you

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go here, you save it.

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And then it's saved. After you saved, you can put send it to the instrument. Or

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you can export it

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into USB drive. So I can export it to either my computer or USB drive. So save.

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Now it's saved in this USB drive. And then I'm ready to use it.

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Is the computer attached or connected to the instrument at all?

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Yeah, so this computer is connected to the instrument through Wi-Fi. Gotcha.

14:47

Yeah, nice. And at our lab, we use an Excel program.

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Yeah. Our sample names and information. So we would be able to export that in

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like a

14:58

CSV file and then load it into the software rather than manually setting up our

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plate.

15:04

Yeah, so you can do that. So basically after you set up the plate using plane

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manager,

15:10

or you have a CSV file installed in the on your computer or USB drive.

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So instead of a computer, can you use your phone to do this?

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Yeah, you can use your smartphone. Do the same thing. You can monitor your rung

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and also you can unlink or link your plate. If you found that after you go home

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or if you are somewhere else far, far away, if you just thought, "Oh, I made a

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mistake."

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So you can make the revision of your protocol using your cell phone or your

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computer remotely.

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Nice. That's really cool. A good feature.

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Yeah. Now the plate is in the same location. You don't even need to come here

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to unlink the plate.

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You can just use that with your... Or set my injection before his.

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I also really loved that each injection was a different color. That was very

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pleasing to the eye.

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Yeah, exactly. Me too.

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So if there's somebody at your lab that always thinks their case is the most

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important and wants

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to jump in front of everybody all the time, is there a way to prevent plates

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from getting

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bumped to the front? I think that would be a very good feature. But all these

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things should

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be tracked in the SAE feature. So we could know who jumped in front of my run.

16:42

Got it.

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Hi, my name is Jimmy Lee. I am a staff engineer at Thermo Fisher. I will be

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showing you the 6-3D

16:53

of flex. So this is the new instrument. So I'll have Ryan come and play with

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the instrument if you

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want to. Sure. All right. So if you want to load, I know Leonton helps you set

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up a plate.

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Right? So here I'm going to hand you that plate. Okay. You can open the drawer.

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So there's positions A, B, C and D. Already two have been filled. So you can

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put it in C or D.

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Okay. I'm going to go with D. Oh, I already... Oh, ZZ. Slide it in. There you

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go. It will lock

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once you close it. But now you can link your plate, which has already been

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loaded on by Leonton.

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So click link plate. Yep. Go to my instrument. And it's right there, the demo 8

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-cap.

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And then you can check all of the properties. So you click on application.

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Click on application.

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Oh, there it is. Okay. ZZ is already on HID 96-wool plate 3600 meter pop-4.

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Click done.

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Go to plate screen. And here we're going to do an injection from column two.

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Okay. Yeah. If you

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want to see what it is, you can go and highlight it. And those are your

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parameters. And you can

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click on the pencil button. And then you can scroll and see all the

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configurations. Nice.

18:12

I stand there. Okay. For the most part, you have your J6 sample in there. Yep.

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Click done.

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And when you're ready to run, click start. Start around. Yeah.

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Is there a way to check the names of the samples that are in there? Go back to

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that pencil.

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You can go to sample name. Click on multiple. And here is where you can enter

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all of your names in.

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Oh, gotcha. Austin's already pre-named him here. Right. There's the eight. And

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then you go to sample

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type and change the... You can go there. And then he's the first one to a

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little glatter.

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The rest are sample. Gotcha. Okay. Cool. Yeah. And then...

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And then... Start. Start around. There you go. Right on.

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You'll do some pre-checks to make sure the consumables are not expired. And

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they'll give you an estimated

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end time. And there it goes. Nice. That starts up really fast. Yeah, it did.

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Did it have to pre-heat?

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So if you didn't preheat your oven, then it will have to pre-heat. You can

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actually do that

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before you run. If you hit that speedometer symbol on the top. Yep. If you

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scroll to the left,

19:12

there is a pre-oven option. But it's already heating up right now. So it's

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disabled. Okay. So you don't have to worry about that. But you see the oven

19:20

temperature is already

19:20

at 31 degrees. So... Do you guys recommend pre-heating? Or is it not necessary?

19:25

If it's already warmed up,

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it'll run faster. How long to preheat? Maybe like 10 minutes before you start

19:30

your run. Yeah.

19:31

I like that the things you can't select are grayed out and things you can are

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blue.

19:36

So you can also turn on the LED to highlight some of the instrument stuff. So

19:40

...

19:41

There. Turn on some of the consumables. Since it's running, you can't really

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open the door.

19:46

But there's that CBC buffer right there. It's going with the polymer pouch and

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then the ABC

19:52

buffer. Same array. Slightly different from the 3500, but similar format here.

19:57

So this is the 24

19:58

cap array. Okay. So you open the oven and you just easily install any one that

20:02

you want to.

20:03

Okay. Did you change anything on the consumables as far as like they can be

20:08

only be on the instrument

20:09

for two weeks? Yeah. So if you go back to the right on the screen, it shows you

20:13

all of your

20:14

status that the consumables. So the capillary, how many injections that's left,

20:18

the polymer,

20:19

and the installation date and the expiration date as well as your buffer. And

20:24

here's your spatial

20:25

calibration, your remaining injections, and then all the calibrations that were

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done for your

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die sets that you can run. And then on this side, you should see some of the

20:33

maintenance stuff that

20:34

needs to be done. Some of them you might need a software update from time to

20:37

time, but it'll tell

20:38

you when you need to do all your maintenance. Okay. And like the wizards kind

20:44

of for that stuff.

20:45

Yeah. Good. Yeah. You want to go to that, the X out of that? Sure. Click on

20:49

action. Click on

20:52

maintenance. Yep. And then maintenance wizards. So here you have a list of

20:58

anything you want to do

21:00

for maintenance. You can change your array, change your polymer type, change

21:03

your buffer,

21:04

change your polymer. And each of them have a video embedded so you can actually

21:07

watch some of them

21:08

for a little bit. So now, like I showed you before, you can actually run

21:13

multiple plates at a time.

21:14

So click home. So now the, it's unlocked so you can open it up. So you put that

21:20

in position to see.

21:21

All right. Oh, lock again. But now you can link a plate. So create a new plate

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file.

21:33

And here you can name your plate. So just click plate name. Yep. Type whatever

21:39

you

21:39

today's day. Okay. Blade two. All right. Enter. Go to application type.

21:47

Like that. Change it from sequencing to XID. Yeah. Done. Yeah. Done. Go to your

21:55

plate.

21:57

And then you can click on the pencil button. Click on injection protocol. One

22:03

time. Yep. And then

22:04

you can pick which die set you want to run. Okay. And then you can change any

22:10

of the

22:10

problems. So this injection protocol free populates these fields for you. If

22:13

you want to do any of

22:14

the custom ones, you can change them here. So done. Done. And start. Start. So

22:22

will it run in the order

22:24

that you set it? So this will run after that first one is done. If you wanted

22:29

to change it,

22:30

since it's already started, you can't do that. But you go to run queue, you'll

22:33

see the order of

22:34

things that will be done. So I can take plate two and go right. Right. It's

22:40

like top of the list.

22:41

Right. So these ones are completed. So plates D is running. So your plate C is

22:45

going to run

22:46

afterwards. So it's in queue. And it'll show you the estimated start at end

22:51

time. Okay. So you have

22:53

to remember where you loaded it. Exactly. Okay. So you can click close. And if

23:01

these since these are already done, you can actually look at some of the data

23:03

on there. So you click on

23:04

the screen. Click real sample list. So that's what we ran. This is just the

23:10

installation run.

23:11

So you click done. Click on action. So you can either unlink, but you want to

23:18

look at the data,

23:19

click on the green icon. And that's what we were with run on that plate. So you

23:24

can use this

23:25

e-gree or the screen to like scroll through, expand that blue bar if you want

23:28

to. That's cool.

23:31

No. Oh. Click on any of those menu, the bullet point buttons.

23:37

And then you can select dies that you want to see. Oh.

23:40

Yep. So you just turned out blue. Oh, turn them off. Okay. Yep. So now you're

23:47

just looking at

23:49

the size standard orange. Oh, there you go. And then when you want to bring the

23:54

samples back in,

23:55

just click on the color again. Yeah. Right. And on the right side, there's

24:00

another option where you

24:03

can zoom in and. Oh, there you go. And then the middle button. It's fine. It's

24:13

your EPT. So it

24:14

shows you the record of all of your, your, your run, nice to the oven

24:18

temperature,

24:19

your current, your voltage throughout your entire run. So same thing, same

24:24

touch face,

24:25

touch me in the face. So, and then when you're done with that, just click done.

24:28

Click done.

24:30

I like that black background. It's so much easier to see the colors than the,

24:35

than the white.

24:36

Yeah. So let's say you want to run another plate. These all are filled. You can

24:40

unlink a plate by

24:41

just pressing B. Do you want to try it? Okay. Sure. I'll link the plate. It's

24:46

going to confirm that

24:46

you want to do that. So now you can open the drawer, remove the plate. And if

24:52

you have another

24:53

one ready to go, you can pop it. Oh, and it shows that it's removed. It will

24:57

sense the plate right

24:58

over there. Yep. It's all I could, I'll take that. Okay. So now you can, you

25:02

know, leave it there,

25:03

load another plate or, you know, awesome. Have it on standby. Yep. Very cool. I

25:08

noticed this is

25:09

your computer now. You're not hooked up to a computer. So currently, we, to do

25:15

like a reboot

25:16

of the system every two weeks, we'll shut down, shut down, restart, restart. So

25:20

you don't need to

25:20

do that for these? Yeah. If you want to restart for any reason, you can just

25:24

power off when no

25:25

place are on there, not running and power back on. Is that something

25:28

recommended or can we just

25:29

leave it on? You can leave it on. Yeah. There's no reason I would need to turn

25:33

it off though.

25:34

Nice. Nice. Yeah. We talked a little bit earlier about having the computer

25:39

in the instrument hooked up to Wi-Fi and being able to control it from your

25:43

phone and everything.

25:44

Forensic labs are always concerned about security. So I wanted to ask about

25:48

that.

25:49

Right. So these instruments can be controlled with SAE. So like the security

25:53

audit and the

25:54

e-signature functions. So if you have it on the network, if anyone logs in,

25:58

they have to have their

25:58

own account login. If they want to start a run, they have to have permission to

26:02

sign off. If you

26:03

don't want to have it on a network, you can have a local computer attached to

26:07

the instrument,

26:08

and it's also controlled by SAE. Wi-Fi free, just local area, just within house

26:13

. So no internet needed.

26:15

Yeah. And then as soon as this run is done, we can access it on the computer,

26:20

any computer,

26:21

with a Wi-Fi on our phone. Yeah. You can do remote access. I do have it on my

26:27

phone. It can

26:28

monitor run and I can show it yet as well.

26:37

So from our remote monitoring app, you can remote monitor your run. So here it

26:41

has a run that's

26:41

already completed. Click on your raw plot. And now Ryan, you can scroll the

26:46

data on the phone,

26:48

just like you would on the flex. Okay. You can see all the peaks. Yep. Yep. And

26:54

you can click on

26:55

different capillaries on top. And then you can filter by color. And then just

27:01

...

27:02

Let's do... Yeah. Apply. There you go. There's your size standard. Yeah.

27:08

Scroll and go to all the capillaries. Yep. Okay. And it will save your

27:14

preference on color. So...

27:16

All right. Nice. There you go. So what's coming off the instrument is being

27:22

correctly...

27:25

screamed to your phone. Exactly. Yep. Like it. Thank you.

27:35

So we'll have a look at the six-year flex a bit. I know we talked about how the

27:44

consumables are the

27:45

same, except from the array. So I just wanted to show you really quickly how

27:48

you can change the

27:49

array in that sort of process. But you could open it up these big barn doors.

27:53

And then if you want

27:55

to open up the array, I mean, this will get you to do it. Just show you how

27:58

easy it is. Open the

28:00

array door. Unscrew the detection cell. Loosen the cap bundle. There you go.

28:12

And then loosen the

28:14

bottom door. It's down here. There you go. And you can slide that out slightly.

28:21

And then you can just use this little handle here and just pull that out of

28:28

there.

28:29

And it will hold it in place. Let's remove it. Great. Where am I? So the very

28:38

nice thing about

28:39

these new arrays are they have to make it easier to do it one-handed. They lock

28:45

in place. So you can

28:46

hold it to and you can install the array one-handed. So it'll stay like this

28:50

when you want to load it

28:51

back into the instrument. Just slide it in place like that. And then you can

28:57

release it. Feed it

29:00

into the bottom. The detection window is automatically there. It's in the right

29:03

place. The instrument

29:04

knows where it is. So you can just tighten everything back up again. Close the

29:08

doors.

29:09

Tighten your football. The feral at the end. And that's it. That's changing the

29:18

array.

29:18

Easy, easy. Wow. Very easy. The nice thing about this instrument, the very cool

29:24

thing is,

29:25

and when you change your array, what do you normally have to do after that?

29:28

You run a special, a spectral and a spatial. Right. So you run the spatial

29:32

because that's how the

29:33

instrument knows where each of the capillaries are. You run the spectral

29:36

because that's teaching

29:37

the instrument the die set that you're going to be using for that. Right. And

29:40

to make sure it's applied

29:41

to this new array. The nice thing about this instrument, you only need to run

29:45

that spectral once.

29:47

That's crazy. Like throughout the entire life of the instrument.

29:51

Correct. The instrument will remember the spectral you have run as long as you

29:55

're running the same

29:56

die set for that chemistry. It will continue to apply that every time you

30:00

change the array.

30:02

That's really cool. It's incredible. Yeah. That's amazing. I'll get them.

30:05

Remember

30:05

it. It makes sure your data is still there. The only time you will ever need to

30:08

run the spectral

30:09

is if you change die sets. So a different type of chemistry. Or you are

30:13

troubleshooting. Wow.

30:15

So I can save you a lot of time running this instrument. Especially it's one of

30:21

those things.

30:22

It's like, I feel like we do it, but not enough to really like learn it well

30:27

every time you do it.

30:28

So it's we never have to learn it again. Exactly. Break out the manual every

30:32

time.

30:33

Every single time. And the other thing. So obviously a lot of these things on

30:37

the instrument,

30:37

you don't have to do that often. So what we do have on this instrument as well

30:41

is to help you

30:42

is called the learning center. So if you go to actions and then learning center

30:48

from here,

30:49

you have helpful videos that you can run that will walk you through when you

30:54

need to do

30:55

different steps on the instrument. So if you want us to learn about how to set

31:00

up a run on the instrument.

31:01

And it will take you through all the steps you need to on how to run and set up

31:14

a run.

31:15

Wow. That's cool. For me, I learned a lot better with videos too. Like, hey,

31:20

here's how you do this.

31:21

Instead of like, you know, reading something that makes it a lot, a lot more

31:25

difficult to be like,

31:26

oh, take the plate and put it here or do this. It's like, oh, video shows you

31:30

exactly how to do it.

31:31

So now we have everything for a visual kinesthetic learners, no matter what you

31:34

do.

31:34

Yep. This is really great for new analysts also. New analysts, maybe analysts

31:41

who haven't

31:41

run the CE in a while, you know, you're just coming back into the lab. It's

31:45

just making it so that

31:46

it's easy. It's approachable and you just know what you're doing. Yeah. Yeah.

31:49

So you can always feel

31:50

confident when you run the CE in a flex. So back to the, you know, kind of old

31:57

school almost like

31:58

barn doors feels nice. But I also like the familiarity with it too. It has kind

32:03

of this,

32:04

you know, you haven't changed everything inside. We don't have to learn an

32:07

entirely new instrument.

32:09

It's just almost like an upgrade to the instruments with a whole bunch of cool

32:14

features.

32:15

All right, guys. We've had a really exciting day and an action-packed day

32:25

learning all about

32:26

the CE to do your flex. I really just want to know what you guys think about it

32:29

. It's awesome.

32:30

I think the design is really sleek. It's user-friendly. You can take your data

32:35

on the go.

32:36

Yes, I love the like onboard computer. So you don't have to restart and link

32:43

these two separate

32:44

things and that you can remote in and from home or from your desk, monitor your

32:49

run,

32:50

set re-injections, put your plate before your co-workers. Exactly. Yeah. And I

32:56

even heard you

32:56

ask some really important questions about data security and stuff while you

32:59

were there. I mean,

33:00

that is something that we know is a huge challenge for forensic labs. The world

33:05

is moving connectivity

33:06

and cloud-based things. And that's why at Thermofisher, we have a group that is

33:09

dedicated to testing

33:11

vulnerabilities on our software and our cloud-based systems. And we have teams

33:16

that are actually

33:16

there helping you so you can bring online and work with your IT groups within

33:20

your lab to figure out

33:21

what is possible to do within your lab. Because what we're finding is there's a

33:25

lot of stuff

33:25

that we can actually do and still be very secure. The old-school methods of

33:29

actually using USBs

33:30

is not the secure method anymore. It's actually having connectivity with

33:34

encryptions and secure

33:36

passwords. So it's going to be really exciting for the future. And this

33:39

instrument is definitely

33:40

going to take us there. I also like the footprint of this instrument. You know,

33:45

for something that

33:45

can hold four plates and kind of run all these things, it's about almost the

33:50

same size as the 3500.

33:51

So it's taken up a nice small amount of space. You know, as long as it's deep

33:57

enough at your lab,

33:58

you can get a couple of these, I think. And you don't need that control

34:02

computer either,

34:03

if you don't need to. So in terms of actual bench real estate, you're a lot

34:07

less. Yeah.

34:09

And being able to put another plate in the queue while one is running, that

34:12

feature I absolutely

34:13

love. I've spent a lot of time waiting for my co-workers to finish up their run

34:18

before I can

34:19

even start prepping my plate. And how do you think that this would benefit you

34:22

in your lab?

34:23

New instruments or kind of new technology comes out like once every five years

34:27

or so I feel like,

34:28

and this is just kind of taking us to that next step of, you know, the fact

34:32

that it has the Wi-Fi

34:33

capability or the cloud-based capability, it just kind of has that feel of, hey

34:39

, we are getting

34:40

into that next generation of instrumentation. So I like it. You know, it's

34:45

staying current with

34:48

everybody else's kind of phones and computers and what we're used to instead of

34:54

running on

34:54

some old instruments. Right. Exactly. And if your lab is not ready for that,

34:58

you can also do it

34:59

the standard way as well. So it's very versatile in that sense. But it's going

35:04

to be ready for

35:04

the future when we're there. Yeah, the fact that you still have the USB, you

35:07

know, people like to

35:08

get in their steps still. So it's like, hey, you don't have to use your phone.

35:12

Go and get those steps

35:14

in, walk to the instrument again, take it off and take it back to your desk.

35:18

And what do you think

35:19

about the onboard learning center? Do you think that will help you in the lab?

35:23

I do. Because I know

35:25

sometimes when you have to like put new polymer on and you haven't had to do

35:29

that in eight months,

35:31

I have to pull out that manual and figure out how to reload my polymer or

35:35

something. So now I can

35:36

just play, see how to do it, pop it on. I don't have to worry about it. Yeah,

35:40

the fact that you can

35:41

actually pause the video too and do that while you're doing it. The doors are

35:47

separate from the

35:48

computer screen. So you can just pause it, do that, okay, click play and

35:53

continue on. It's nice.

35:54

And watching the video of it happening in real time is a lot easier than having

35:59

to read through

36:00

the wizard like we do now. So that's really nice. And what about the startup

36:04

sequence?

36:05

Have you guys think about that? I think it's great because currently, like I

36:09

said earlier with the

36:11

computer next to your instrument, you have to turn this off, turn this off,

36:16

turn this on, turn this

36:17

on, wait for a green light, open your software. So now it's just one button,

36:22

turn the instrument on

36:23

and you're ready to go. And what do you think about the array? This was

36:26

absolutely amazing. So can I?

36:28

Yeah, please. So you literally just squeeze that and it releases. That's really

36:35

cool. That was

36:36

something I didn't know that I needed. Yeah, exactly. No more fumbling around

36:40

with the detection cell

36:41

window, trying to get that in place with the magnets and then making sure it's

36:45

just right.

36:46

Not breaking it. Not breaking the array. That's key as well. But yeah. Yeah, I

36:52

was always worried.

36:53

I'm like, "Oh, capillary needs to be changed." I'm like, "Maybe I'll just

36:56

pretend I didn't see it on

36:58

the instrument. Someone else will change it because it's like this thing is

37:01

like, you know, kind of

37:02

all over the place. So it's nice that it's everything's kind of in place. You

37:06

know, a couple clicks,

37:07

a couple knobs to turn and it's in and ready to go. Yeah, you can do it 100.

37:13

No more three hands and tape kneaders. I know we've had an action-packed day.

37:18

It has been super

37:19

exciting from our side. Then we're Fisher Scientific has loved having you here.

37:22

So thank you so much

37:23

for taking the time. It has been great. I really hope you got a lot out of it

37:27

and I can't wait until

37:28

the next video. Thanks so much for having us. This is wonderful. I had a blast.

37:32

You were the first

37:33

accredited forensic scientist to do a run on the HID version of the Seac Studio

37:38

Flex. This is great.

37:40

Thank you guys so much. Thank you. Thank you.

37:48

[end]

37:54

[ Silence ]